MAPPING THE LANDSCAPE OF BIOMATERIALS IN ORTHOPAEDICS: A BIBLIOMETRIC ANALYSIS OF GLOBAL RESEARCH TRENDS 2010-2025

Authors

DOI:

https://doi.org/10.24036/4ca30154

Keywords:

Bibliometric Analysis; Orthopaedic Biomaterials; Sustainable Development Goals; Biocompatibility; Tissue Engineering

Abstract

The aim of this bibliometric analysis is to investigate the global scientific crash report on orthopaedic biomaterials from 2010 to 2025, with emphasis on their significant contribution for Sustainable Development Goal 3 (Good Health and Well-being). The analysis is based on 3,322 documents identified in the Scopus database, and publication productivity, collaborative networks and emerging thematic clusters are mapped using VOSviewer. Results The number of publications and their contribution in this subspecialty are increasing enormously, mainly from China, the US and India, but also from European countries. Four research directions were most identified: medical applications of biomaterials, bone tissue engineering, cellular and animal studies, and antibacterial nanomaterials. General keywords such as biocompatibility, tissue engineering, and 3D printing emphasize the trend toward personalized implants, new regenerative strategies, and improved implant life span. The review also highlights underexplored fields including drug delivery systems, angiogenesis, and corrosion resistance, which shows valuable leads for upcoming studies. The multidisciplinary nature of the field that delves into not only materials science and engineering but also into biology and clinical medicine necessarily calls for global collaboration and ingenuity to create sustainable, effective and accessible orthopaedic solutions. This analysis presents as a strategic reference point that can inform subsequent science and policy related to the improvement of musculoskeletal health internationally.

Author Biographies

  • Syafri, Universitas Negeri Padang

    1Department of Physics, Faculty Science, Padang State University, Padang, Indonesia 25131

    3Indonesia Computational Research Consortium on Renewable Energy (ICRC-RE), IPB University, Bogor 16680, Indonesia

  • Ratnawulan, Universitas Negeri Padang

    1Department of Physics, Faculty Science, Padang State University, Padang, Indonesia 25131

  • Riri Jonuarti, Universitas Negeri Padang

    1Department of Physics, Faculty Science, Padang State University, Padang, Indonesia 25131

  • Husin Alatas, IPB University

    2Theoretical Physics Division, Department of Physics, Jl. Meranti, Kampus IPB Darmaga, IPB University, Bogor 16680, Indonesia

    3Indonesia Computational Research Consortium on Renewable Energy (ICRC-RE), IPB University, Bogor 16680, Indonesia

    4Center for Transdisciplinary & Sustainability Sciences (CTSS), IPB University, Kampus IPB Baranangsiang, Jl. Raya Pajajaran 27, Bogor 16128

  • Faozan Ahmad, IPB University

    2Theoretical Physics Division, Department of Physics, Jl. Meranti, Kampus IPB Darmaga, IPB University, Bogor 16680, Indonesia

    3Indonesia Computational Research Consortium on Renewable Energy (ICRC-RE), IPB University, Bogor 16680, Indonesia

  • Aditya Wibawa Sakti, Waseda University

    3Indonesia Computational Research Consortium on Renewable Energy (ICRC-RE), IPB University, Bogor 16680, Indonesia

    5Waseda Research Institute for Science and Engineering (WISE), Waseda University, Tokyo 169-8555, Japan

References

[1] D. Unune, G. Brown, and G. Reilly, “Thermal based surface modification techniques for enhancing the corrosion and wear resistance of metallic implants: a review,” Vacuum, vol. 203, p. 111298, 2022, doi: 10.1016/j.vacuum.2022.111298.

[2] M. İzmir, Y. Tufan, G. Tan, and B. Ercan, “Ti6al4v foams having nanotubular surfaces for orthopaedic applications,” Surf. Interface Anal., vol. 51, no. 9, pp. 954–963, 2019, doi: 10.1002/sia.6687.

[3] H. Joo, S. Wu, I. Soni, C. Wang-Crocker, T. Matern, and J. Beck, “Phage and antibiotic combinations reduce staphylococcus aureus in static and dynamic biofilms grown on an implant material,” Viruses, vol. 15, no. 2, p. 460, 2023, doi: 10.3390/v15020460.

[4] G. Szczęsny, M. Kopeć, D. Politis, Z. Kowalewski, A. Łazarski, and T. Szolc, “A review on biomaterials for orthopaedic surgery and traumatology: from past to present,” Materials (Basel)., vol. 15, no. 10, p. 3622, 2022, doi: 10.3390/ma15103622.

[5] M. Sarraf, E. Ghomi, S. Alipour, S. Ramakrishna, and N. Sukiman, “A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications,” Bio-Design Manuf., vol. 5, no. 2, pp. 371–395, 2021, doi: 10.1007/s42242-021-00170-3.

[6] K. Janatzai, O. Walikhan, and K. Tajmohammad, “An insight into the orthopaedic implant materials: a comprehensive study,” J. Appl. Pharm. Sci. Res., vol. 5, no. 3, pp. 28–33, 2022, doi: 10.31069/japsr.v5i3.03.

[7] G. Caruso, M. Andreotti, C. Pari, F. Soldati, A. Gildone, and V. Lorusso, “Can tad and caltad predict cut-out after extra-medullary fixation with new generation devices of proximal femoral fractures? a retrospective study,” J. Clin. Orthop. Trauma, vol. 8, no. 1, pp. 68–72, 2017, doi: 10.1016/j.jcot.2016.09.009.

[8] L. Jia, F. Han, H. Wang, C. Zhu, Q. Guo, and J. Li, “Polydopamine-assisted surface modification for orthopaedic implants,” J. Orthop. Transl., vol. 17, pp. 82–95, 2019, doi: 10.1016/j.jot.2019.04.001.

[9] C. Mas-Moruno, B. Su, and M. Dalby, “Multifunctional coatings and nanotopographies: toward cell instructive and antibacterial implants,” Adv. Healthc. Mater., vol. 8, no. 1, 2018, doi: 10.1002/adhm.201801103.

[10] P. Pesode, S. Barve, S. Wankhede, and A. Ahmad, “Sustainable materials and technologies for biomedical applications,” Adv. Mater. Sci. Eng., vol. 2023, pp. 1–22, 2023, doi: 10.1155/2023/6682892.

[11] I. Roohani, E. Newsom, and H. Zreiqat, “High-resolution vat-photopolymerization of personalized bioceramic implants: new advances, regulatory hurdles, and key recommendations,” Int. Mater. Rev., vol. 68, no. 8, pp. 1075–1097, 2023, doi: 10.1080/09506608.2023.2194744.

[12] N. Kanakaris and P. Giannoudis, “Biofilm and its implications postfracture fixation: all i need to know,” OTA Int. Open Access J. Orthop. Trauma, vol. 4, no. 3S, p. e107, 2021, doi: 10.1097/oi9.0000000000000107.

[13] J. Haglin, A. Eltorai, J. Gil, S. Marcaccio, J. Botero, and A. Daniels, “Patient-specific orthopaedic implants,” Orthop. Surg., vol. 8, no. 4, pp. 417–424, 2016, doi: 10.1111/os.12282.

[14] M. Ishak, X. Liu, J. Jenkins, A. Nobbs, and B. Su, “Protruding nanostructured surfaces for antimicrobial and osteogenic titanium implants,” Coatings, vol. 10, no. 8, p. 756, 2020, doi: 10.3390/coatings10080756.

[15] C. Chen, L. Cai, W. Zheng, J. Wang, X. Guo, and H. Chen, “The efficacy of using 3d printing models in the treatment of fractures: a randomised clinical trial,” BMC Musculoskelet. Disord., vol. 20, no. 1, 2019, doi: 10.1186/s12891-019-2448-9.

[16] G. Im, “Biomaterials in orthopaedics: the past and future with immune modulation,” Biomater. Res., vol. 24, no. 1, 2020, doi: 10.1186/s40824-020-0185-7.

[17] K. Prasad, O. Bazaka, M. Chua, M. Rochford, L. Fedrick, and J. Spoor, “Metallic biomaterials: current challenges and opportunities,” Materials (Basel)., vol. 10, no. 8, p. 884, 2017, doi: 10.3390/ma10080884.

[18] A. Pang, Z. Liau, J. Oh, and D. Srinivasan, “Nanotechnology-enhanced orthopaedic surgery,” J. Nanotheranostics, vol. 5, no. 4, pp. 167–187, 2024, doi: 10.3390/jnt5040011.

[19] W. Liang, C. Zhou, J. Bai, H. Zhang, H. Long, and B. Jiang, “Current developments and future perspectives of nanotechnology in orthopedic implants: an updated review,” Front. Bioeng. Biotechnol., vol. 12, 2024, doi: 10.3389/fbioe.2024.1342340.

[20] J. Shang, C. Zhou, C. Jiang, X. Huang, Z. Liu, and H. Zhang, “Recent developments in nanomaterials for upgrading treatment of orthopedics diseases,” Front. Bioeng. Biotechnol., vol. 11, 2023, doi: 10.3389/fbioe.2023.1221365.

[21] J. Wang, C. Yuan, B. Yang, Q. Zhang, D. Wang, and X. He, “The application of biomaterials in osteogenesis: a bibliometric and visualized analysis,” Front. Bioeng. Biotechnol., vol. 10, 2022, doi: 10.3389/fbioe.2022.998257.

[22] K. Tetsworth, S. Block, and V. Glatt, “Putting 3d modelling and 3d printing into practice: virtual surgery and preoperative planning to reconstruct complex post-traumatic skeletal deformities and defects,” Sicot-J, vol. 3, p. 16, 2017, doi: 10.1051/sicotj/2016043.

[23] U. Persad and M. Mencia, “The value of 3d printing in orthopaedics,” Caribb. Med. J., 2020, doi: 10.48107/cmj.2020.11.005.

[24] C. Kelly and S. Adams, “3d printing materials and technologies for orthopaedic applications,” J. Orthop. Trauma, vol. 38, no. 4S, pp. S9–S12, 2024, doi: 10.1097/bot.0000000000002765.

[25] A. Vasiliadis, N. Koukoulias, and K. Katakalos, “Three-dimensional-printed scaffolds for meniscus tissue engineering: opportunity for the future in the orthopaedic world,” J. Funct. Biomater., vol. 12, no. 4, p. 69, 2021, doi: 10.3390/jfb12040069.

[26] J. Wang, Y. Yu, J. Guo, W. Lü, Q. Wei, and Y. Zhao, “The construction and application of three‐dimensional biomaterials,” Adv. Biosyst., vol. 4, no. 2, 2020, doi: 10.1002/adbi.201900238.

[27] R. Venter, L. Kotzé, and N. Ferreira, “A clinician-run 3d-printing laboratory for orthopaedic preoperative planning: an illustrative case series,” SA Orthop. J., vol. 61, no. 3, pp. 181–186, 2022, doi: 10.17159/2309-8309/2022/v21n3a7.

[28] L. Chen, “Deciphering the circadian rhythm in colorectal cancer: a bibliometric analysis of research landscape and trends,” Front. Oncol., vol. 15, 2025, doi: 10.3389/fonc.2025.1591257.

[29] L. Alaoui, Y. Hammoudani, K. Haboubi, and F. Dimane, “Evolution of global climate change related research: bibliometric analysis,” E3S Web Conf., vol. 527, p. 1003, 2024, doi: 10.1051/e3sconf/202452701003.

[30] A. Muktamar, S. Wahdiniawat, F. Fatmawati, and B. Mardikawati, “Challenges and opportunities in hrm research in the era of globalization: a bibliometric analysis of the effects of cultural diversity and innovation in organizations,” West Sci. Interdiscip. Stud., vol. 1, no. 11, pp. 1177–1186, 2023, doi: 10.58812/wsis.v1i11.342.

[31] L. Judijanto and W. Widyatmoko, “Bibliometric analysis of the development of entrepreneurial ecosystem research in global publications,” West Sci. Bus. Manag., vol. 2, no. 03, pp. 920–935, 2024, doi: 10.58812/wsbm.v2i03.1272.

[32] G. Aarons, C. Seijo, A. Green, J. Moullin, H. Hasson, and U. Schwarz, “Fostering international collaboration in implementation science and research: a concept mapping exploratory study,” BMC Res. Notes, vol. 12, no. 1, 2019, doi: 10.1186/s13104-019-4800-4.

[33] A. Vélez-Estévez, P. García-Sánchez, J. Moral-Muñoz, and M. Cobo, “Why do papers from international collaborations get more citations? a bibliometric analysis of library and information science papers,” Scientometrics, vol. 127, no. 12, pp. 7517–7555, 2022, doi: 10.1007/s11192-022-04486-4.

[34] E. Nicholson, T. Murphy, P. Larkin, C. Normand, and S. Guérin, “Protocol for a thematic synthesis to identify key themes and messages from a palliative care research network,” BMC Res. Notes, vol. 9, no. 1, 2016, doi: 10.1186/s13104-016-2282-1.

[35] X. Xu, Z. Shen, Y. Shan, F. Sun, Y. Lü, and J. Zhu, “Application of tissue engineering techniques in tracheal repair: a bibliometric study,” Bioengineered, vol. 14, no. 1, 2023, doi: 10.1080/21655979.2023.2274150.

[36] Q. Gao, X. Li, Y. Li, J. Long, M. Pan, and J. Wang, “Bibliometric analysis of global research trends on regulatory t cells in neurological diseases,” Front. Neurol., vol. 14, 2023, doi: 10.3389/fneur.2023.1284501.

[37] D. Zhang, W. Zhu, J. Guo, W. Chen, and X. Gu, “Application of artificial intelligence in glioma researches: a bibliometric analysis,” Front. Oncol., vol. 12, 2022, doi: 10.3389/fonc.2022.978427.

[38] A. Maulani and R. Widuri, “Bibliometric analysis: adoption of big data analytics in financial auditing,” Bus. Informatics, vol. 18, no. 2, pp. 78–89, 2024, doi: 10.17323/2587-814x.2024.2.78.89.

[39] B. Liu, X. Gao, and Y. Piao, “Trends and frontiers of rna methylation in cancer over the past 10 years: a bibliometric and visual analysis,” Front. Genet., vol. 15, 2024, doi: 10.3389/fgene.2024.1461386.

[40] Z. Zhang, M. Yang, T. Zhou, Y. Chen, X. Zhou, and K. Long, “Emerging trends and hotspots in intestinal microbiota research in sepsis: bibliometric analysis,” Front. Med., vol. 11, 2024, doi: 10.3389/fmed.2024.1510463.

[41] S. Osorio-Toro, A. Campo, and H. Ramírez-Malule, “Bibliometric analysis of global research output on teaching and learning of human anatomy,” Int. J. Morphol., vol. 40, no. 3, pp. 789–795, 2022, doi: 10.4067/s0717-95022022000300789.

[42] Z. Jiang, C. Wu, S. Hu, N. Liao, Y. Huang, and H. Ding, “Research on neck dissection for oral squamous-cell carcinoma: a bibliometric analysis,” Int. J. Oral Sci., vol. 13, no. 1, 2021, doi: 10.1038/s41368-021-00117-5.

[43] R. Watrianthos, A. Ambiyar, F. Rizal, N. Jalinus, and W. Waskito, “Research on vocational education in indonesia: a bibliometric analysis,” JTEV (Jurnal Tek. Elektro Dan Vokasional), vol. 8, no. 2, p. 187, 2022, doi: 10.24036/jtev.v8i2.117045.

[44] S. Zhang, H. Yan, D. Cao, W. Sun, J. Li, and J. Xu, “Research hotspots and trends in diabetes and insulin resistance: a bibliometric analysis,” Front. Nutr., vol. 11, 2024, doi: 10.3389/fnut.2024.1480491.

[45] Y. Sun, “Nanotechnology and biomaterials in orthopaedic medical applications,” Highlights Sci. Eng. Technol., vol. 73, pp. 88–95, 2023, doi: 10.54097/hset.v73i.12844.

[46] T. Tang and L. Qin, “Translational study of orthopaedic biomaterials and devices,” J. Orthop. Transl., vol. 5, pp. 69–71, 2016, doi: 10.1016/j.jot.2016.02.001.

[47] M. Sylvestre, C. Crane, and S. Pun, “Progress on modulating tumor‐associated macrophages with biomaterials,” Adv. Mater., vol. 32, no. 13, 2019, doi: 10.1002/adma.201902007.

[48] G. Singh, “A bibliometric analysis and visualisation of research trends in titanium-based orthopaedic implants,” Turkish J. Comput. Math. Educ., vol. 12, no. 2, pp. 69–74, 2021, doi: 10.17762/turcomat.v12i2.678.

[49] H. Ashel, I. Hamidah, S. Anwar, and M. Muslim, “Research Trends of Mental Models and Opportunity in Science Education: a Bibliometric Analysis,” J. Eng. Sci. Technol., vol. 18, no. 6, pp. 70–80, 2023.

[50] I. Zupic and T. Čater, “Bibliometric methods in management and organization,” Organ. Res. Methods, vol. 18, no. 3, pp. 429–472, 2015.

[51] N. J. Van Eck and L. Waltman, “Software survey: VOSviewer, a computer program for bibliometric mapping,” Scientometrics, vol. 84, no. 2, pp. 523–538, 2010, doi: 10.1007/s11192-009-0146-3.

[52] N. J. van Eck and L. Waltman, “Visualizing Bibliometric Networks BT - Measuring Scholarly Impact,” Springer International Publishing, 2014, pp. 285–320. doi: 10.1007/978-3-319-10377-8_13.

[53] A. Maleki, Z. D. Deilami, and D. Haseli, “Exploring Social Networks and Conceptual Structure in Accounting Research: A Study of Scientific Collaboration and Word Co-occurrence,” 2024, doi: 10.22034/ijism.2024.2005663.1163.

[54] E. Fahrati and Y. Sopiana, “Knowledge Mapping in Agricultural Economics,” West Sci. Nat. Technol., vol. 2, no. 02, pp. 118–127, 2024, doi: 10.58812/wsnt.v2i02.1016.

[55] Y. Xu, “Academic Research Trend Analysis in the Past Twenty-five Years of Electric Vehicle Industry by Network Visualisation,” Appl. Comput. Eng., vol. 128, no. 1, pp. 176–182, 2025, doi: 10.54254/2755-2721/2025.20464.

[56] Q. Yanling and J. Fanfan, “Visualizing and Metrically Analyzing Smart Logistics Literature Based on WOS and VOSviewer,” 2024. doi: 10.1109/icmss61211.2024.00027.

[57] T. Ara’ujo, A. Abreu, and F. Louçã, “The evolution of Complexity co-occurring keywords: bibliometric analysis and network approach,” arXiv.Org, abs/2308.00992, 2023, doi: doi.org/10.48550/arxiv.2308.00992.

[58] P. Dubey, P. K. Agrawal, H. Chourasia, M. Nayak, and H. Gehani, “Bibliometric Analysis of Data Science Research: A Decade of Insights from Web of Science,” 2023 Fourth Int. Conf. Smart Technol. Comput. Electr. Electron., pp. 1–6, 2023, doi: 10.1109/icstcee60504.2023.10585030.

[59] N. Gupta and R. Chakravarty, “Research visualization of Indian LIS research using VOSviewer and Bibliometrix,” Libr. Hi Tech News, vol. 38, no. 8, pp. 6–8, 2021, doi: 10.1108/LHTN-10-2021-0076.

[60] H. B. de Arruda, É. R. Silva, M. A. Lessa, D. Proença, and R. Bartholo, “VOSviewer and Bibliometrix,” J. Med. Libr. Assoc., vol. 110, no. 3, pp. 392–395, 2022, doi: 10.5195/jmla.2022.1434.

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Published

2025-10-31

How to Cite

MAPPING THE LANDSCAPE OF BIOMATERIALS IN ORTHOPAEDICS: A BIBLIOMETRIC ANALYSIS OF GLOBAL RESEARCH TRENDS 2010-2025. (2025). PILLAR OF PHYSICS, 18(2), 81-95. https://doi.org/10.24036/4ca30154